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DEFINITION: (adjective) Full of mettle; spirited and plucky. SYNONYMS: spirited, game, gritty, spunky. USAGE: Joe, being a mettlesome fellow, returned the stranger's angry glance with a steady look.

Watson is an American biologist who, with Francis Crick, researched the molecular structure of deoxyribonucleic acid (DNA) at Cambridge in the 1950s. Their findings earned them and M.H.F. Wilkins the 1962 Nobel Prize in Physiology or Medicine. Watson later became director of the Cold Spring Harbor Laboratory in NY and served as director of the National Center for Human Genome Research, which undertook the Human Genome Project. At the age of 12, Watson appeared on what popular radio show?

The Twinkie was invented by bakery manager James Dewar, who made thrifty use of shortcake pans that had previously been used only during the strawberry season. Twinkies originally contained a banana filling, but this was replaced with a vanilla filling during a banana shortage caused by the outbreak of World War II. Today, five hundred million Twinkies are produced each year. What is the "Twinkie defense," and when was the term first used?

Rosenborg Castle is situated at the center of the Danish capital, Copenhagen. It was built in 1606 in the Dutch Renaissance style and went through several expansions to arrive at its present condition in 1624. It was used by Danish regents as a royal residence until around 1710 and was opened to the public in 1838. Today, it is popular with tourists who flock to the castle to view the Danish Crown Regalia. How many people visit the Rosenborg Castle Garden every year?