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Women with multiple sclerosis (MS) now appear to outnumber men with the disease by a ratio of 4 to 1 in the US. A review of data suggests a steady increase in MS rates among women over time, while rates among men appear to have remained stable. Experts says more research is needed to explore the changes that have occurred for women over the last few decades, such as the introduction of the 'Pill', earlier menstruation, and later age of first births.