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Isabella d'Este was one of the leading women of the Italian Renaissance and a major cultural and political figure. Known as "The First Lady of the Renaissance," she was well-educated in her youth and was a keen musician and collector of Roman sculpture. Under her auspices, the court of Mantua became one of the most cultured in Europe, drawing many important artists, writers, and thinkers. The portrait of her that hangs at the Louvre in Paris was painted by what famous artist and scientist?