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These frogs belong to the family Dendrobatidae, a group of small, diurnal, often brightly colored frogs native to Central and South America. These frogs secrete poisonous alkaloids through their skin, which ranges in color from bright orange to black and blue. Most poison frogs are not toxic to humans or animals, but a few secrete a potent neurotoxin that can kill within minutes. Why is it that poison frogs captured from the wild and fed a typical captive diet lose their toxicity?